In the original series (seasons 1–4), Dr. Sara Tancredi appears to die at the end of Season 3. Her death is revealed in the Season 4 premiere ("Scylla") when Michael Scofield receives a box containing her severed head. The show explains that she was killed by Gretchen Morgan and The Company to punish Michael for escaping Sona prison without helping them.
However, if you are referring to the — as of now (April 2026), there is no official new Prison Break season or film where Sara dies. Any recent "Sarah death" post would be fan speculation or misinformation. prison break sarah death